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GABAergic input through GABAB receptors is necessary during a perinatal window to shape gene expression of factors critical to reproduction such as Kiss1.
Bizzozzero-Hiriart M, Di Giorgio NP, Libertun C, Lux-Lantos V. Bizzozzero-Hiriart M, et al. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E901-E919. doi: 10.1152/ajpendo.00547.2019. Epub 2020 Apr 14. Am J Physiol Endocrinol Metab. 2020. PMID: 32286880 Free article.
Our most important findings on PND6 include the CGP-induced decrease in ARC Kiss1 and increase in neurokinin B (Tac2) in both sexes; the decrease in AVPV/PeN tyrosine hydroxylase (Th) only in females; the increase in gonad estradiol content in both sexes; and the increase …
Our most important findings on PND6 include the CGP-induced decrease in ARC Kiss1 and increase in neurokinin B (Tac2) in both sexes; …
Hypothalamic molecular changes underlying natural reproductive senescence in the female rat.
Kermath BA, Riha PD, Woller MJ, Wolfe A, Gore AC. Kermath BA, et al. Endocrinology. 2014 Sep;155(9):3597-609. doi: 10.1210/en.2014-1017. Epub 2014 Jun 10. Endocrinology. 2014. PMID: 24914937 Free PMC article.
Affected genes included transcription factors (Stat5b, Arnt, Ahr), sex steroid hormone receptors (Esr1, Esr2, Pgr, Ar), steroidogenic enzymes (Sts, Hsd17b8), growth factors (Igf1, Tgfa), and neuropeptides (Kiss1, Tac2, Gnrh1). Bionetwork analysis revealed region-spe …
Affected genes included transcription factors (Stat5b, Arnt, Ahr), sex steroid hormone receptors (Esr1, Esr2, Pgr, Ar), steroidogenic enzyme …